Heparin-Induced Thrombocytopenia: Historical Review
نویسندگان
چکیده
منابع مشابه
Heparin induced thrombocytopenia
Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...
متن کاملHeparin-induced thrombocytopenia: a historical perspective.
Heparin was discovered 90 years ago,1 and within 2 decades it was being widely used as an anticoagulant.2 The numerous advantages of heparin lend to its broad use including its immediate onset of action, relatively short half-life ( 60 minutes), simple laboratory monitoring (aPTT), ability to be reversed (using protamine), and low cost. Despite a long experience of using heparin, the counterint...
متن کاملHeparin-induced thrombocytopenia: a review.
Immune heparin-induced thrombocytopenia (HIT) is a relevant adverse drug reaction consisting in a hypercoagulable state caused by an anticoagulant agent. The incidence is approximately 6.5% in patients receiving unfractionated heparin after orthopedic surgery, and is equal to or lower than 1% in other settings. HIT occurrence is a function of heparin type, duration of heparin administration, pa...
متن کاملProgress Review Heparin-Induced Thrombocytopenia
There are two types of heparin-induced thrombocytopenia. Type I is more common, has an early onset, and is mild, transient, and benign. Type I is due to direct heparin-induced platelet aggregation and is rarely associated with thromboembolic sequela. Type II is infrequent, has a late onset, and is more severe. Type II is due to an immune-mediated platelet aggregation caused by IgG and IgM that ...
متن کاملCurrent concepts review: heparin-induced thrombocytopenia.
Immune-type (Type II) heparin-induced thrombocytopenia (HIT) is a rare but potentially fatal complication that can result from the use of heparin or its derivatives employed to reduce the risk of venous thromboembolic disease (VTED) after surgery. As such, the onset of HIT creates a therapeutic paradox: VTED prophylaxis that induces systemic thrombosis. Orthopaedic patients often necessitate ch...
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ژورنال
عنوان ژورنال: Clinical and Applied Thrombosis/Hemostasis
سال: 1999
ISSN: 1076-0296,1938-2723
DOI: 10.1177/10760296990050s102